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There Are More than 100 Autoimmune Diseases, and They Mostly Strike Women. Here's What to Know

Women represent about 80% of autoimmune disease cases, which involve over 100 chronic illnesses caused by immune system attacks on the body's tissues.

  • Autoimmune diseases comprise more than 100 chronic illnesses, affecting tens of millions worldwide with women making up about 4 of 5 patients.
  • Scientists point to genetic susceptibility combined with environmental triggers such as infections, smoking, or pollutants, and loss of immune tolerance, while sex-based biology including two X chromosomes in females also contributes.
  • Often, diagnosis starts with vague symptoms that come and go, as many autoimmune diseases mimic other illnesses; patients undergo multiple tests and see several doctors before diagnosis, with diseases like Sjögren's disease, rheumatoid arthritis and psoriatic arthritis, and lupus affecting different organs.
  • Treatment has shifted from broad suppression to targeted molecular therapies, with dozens of clinical trials testing immune reprogramming and the global market valued at $100 billion a year.
  • The National MS Society is pushing updated guidelines to streamline multiple sclerosis diagnosis, noting lupus is higher in Black and Hispanic women while Northern Europeans have greater MS risk; VEXAS syndrome, discovered in 2020, affects men over 50.
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There are more than 100 autoimmune diseases, and they mostly strike women. Here's what to know

Autoimmune diseases can affect just about every part of the body – and tens of millions of people. While most common in women, these diseases can strike anyone, adults or children, and they’re on the rise.

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WKTV broke the news in on Thursday, November 6, 2025.
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