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Blood Test May Predict Rapid Brain Decline in Alzheimer's Patients
ITALY, JUN 23 – A blood test measuring insulin resistance identifies Alzheimer’s patients with a fourfold increased risk of rapid cognitive decline, aiding early intervention and targeted therapies.
- Scientists from BGI Genomics’ research institute focused on intelligent medical studies recently published findings in early June 2025 that reveal initial indicators and specific neuron types linked to the development of Alzheimer’s disease.
- The study used Smart-seq2 to analyze over 1,663 single-cell transcriptomes in the entorhinal cortex-hippocampal circuit, a key memory region affected early by Alzheimer's.
- Researchers found mitochondria fail early in disease progression, neurons produce glial-like protein GFAP, and insulin resistance worsens Alzheimer's by disrupting brain function and the blood-brain barrier.
- Dr. Bianca Gumina reported that a simple metabolic blood test, the triglyceride-glucose index, predicts which patients will face faster cognitive decline, with those in the highest third quadrupling risk.
- These findings suggest targeting metabolism could slow Alzheimer's progression, creating therapy opportunities alongside emerging disease-modifying drugs to improve early intervention strategies.
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·London, United Kingdom
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Daily Journal+14 Reposted by 14 other sources
Study finds blood test can predict cognitive decline in dementia patients
“We were surprised to see the effect only in the Alzheimer’s spectrum and not in other neurodegenerative diseases."
·Cherokee County, United States
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Total News Sources64
Leaning Left6Leaning Right8Center18Last UpdatedBias Distribution56% Center
Bias Distribution
- 56% of the sources are Center
56% Center
L 19%
C 56%
R 25%
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