The Relevance of Long-Lived Molecules to Aging Remains Speculative

The Relevance of Long-Lived Molecules to Aging Remains Speculative

Some long-lived proteins (such as components of nuclear pore structures) in some long-lived cells (such as neurons) may never be replaced across a normal life span, or at the very least have lifetimes of years. That suggests that damage to these molecules may be important in aging and age-related disease. Some research has taken place on this topic, but as noted here, issues of measurement ensure that damage to long-lived molecules remains a mor…