US EditionThe Nobel Prize in medicine goes to 3 scientists for work on peripheral immune tolerance
The trio’s discoveries on regulatory T cells have launched new research fields and potential treatments for cancer and autoimmune diseases, sharing a $1.2 million prize.
- The Nobel Assembly at the Karolinska Institute, Stockholm announced on October 6, 2025 that Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi won the 2025 Nobel Prize in Physiology or Medicine for discoveries concerning peripheral immune tolerance.
- The Nobel panel described peripheral immune tolerance as the process preventing the immune system from attacking the body’s own tissues, crucial for avoiding autoimmune disease.
- In 1995, Shimon Sakaguchi showed a new immune cell class and later linked the Foxp3 gene to their development, while Mary E. Brunkow and Fred Ramsdell connected Foxp3 mutations to IPEX in 2001.
- The Nobel Assembly said `Their discoveries have laid the foundation for a new field of research and spurred the development of new treatments, for example for cancer and autoimmune diseases`, with over 200 clinical trials now underway for regulatory T cells and Foxp3-based therapies.
- The laureates will receive their awards on December 10 in Stockholm, sharing 11 million Swedish kronor and collecting a diploma and gold medal as medicine opens this week’s Nobel announcements.
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Swedish Academy highlighted that the findings of Mary E. Brunkon, Fred Ramsdell and Shimon Sakaguchi have been decisive in understanding the immune system
The Nobel Prize in Medicine this year goes to the two US researchers Mary E. Brunkow and Fred Ramsdell as well as to the Japanese Shimon Sakaguchi. According to the Nobel Committee in Stockholm, they are awarded for their findings on the human immune system.
The work of Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi on peripheral immunological tolerance explains an essential mechanism of the immune system, key to treating autoimmune diseases, cancer and facilitating transplants.
Professor Shimon Sakaguchi, who won the Nobel Prize in Medicine on Monday, is a visiting professor at the University of Turku in a project studying the immune system.
U.S.–Japanese Trio Win Medicine Nobel for Immune System Research
Mary E. Brunkow and Fred Ramsdell of the United States and Japan’s Shimon Sakaguchi won the Nobel Prize in Medicine on Monday, October 6th, for research into how the immune system is kept in check, the Nobel jury said. Their discoveries have been decisive for understanding how the immune system functions and why we do not all develop serious autoimmune diseases. The three were honoured “for their discoveries concerning peripheral immune toleranc…
On Monday, the Karolinska Institute in Stockholm, Sweden, awarded the Nobel Prize in Physiology or Medicine to American scientists Mary Brunkow and Fred Ramsdell, and Japanese Shimon Sakaguchi “for their discoveries about peripheral immune tolerance.” The winners identified the “immune system safety guards,” regulatory T cells, which prevent the immune system from attacking our own body, as the committee explained.
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