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Testing Is Underway on Vaccines to Intercept Brewing Colon Cancer Before It Takes Root

Early trial data showed the shots boosted tumor-fighting T cells and left participants with fewer precancerous growths, researchers said.

  • Scientists are advancing experimental vaccines designed to intercept colon cancer in people with Lynch syndrome, as Dr. Eduardo Vilar-Sanchez of the Anderson Cancer Center expects a larger study to begin early next year.
  • Roughly 1 million Americans carry Lynch syndrome, a faulty DNA mismatch-repair gene disorder that raises lifetime colorectal cancer risk to as high as 80 percent, compared to around 5 percent for the general population.
  • In a recent study, 44 Lynch carriers tested a vaccine from Swiss biotech Nouscom targeting 209 abnormal protein markers, boosting tumor-fighting T cells and resulting in fewer precancerous growths and no advanced polyps.
  • Houston physician Dr. Stacy Norton, a study participant who lost family members to cancer, said the vaccine offers hope, noting, "perhaps they won't have to have a colonoscopy every single year for the rest of their lives."
  • Additional vaccine candidates are under development, including a Moderna mRNA vaccine in Britain and a California-based ImmunityBio Tri-Ad5 shot being compared against placebo, aiming to train the immune system to recognize cancer markers.
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Testing is underway on vaccines to intercept brewing colon cancer before it takes root

A shot to prevent cancer? Scientists are testing vaccines designed to stop certain tumors before they form.

·Oklahoma City, United States
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The Sun Newspapers broke the news on Sunday, August 9, 2026.
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