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'Fossil record' in stored blood samples lets scientists trace leukemia back decades before diagnosis

Summary by Medical Xpress
Scientists have reconstructed how acute myeloid leukemia (AML) develops over the decades before diagnosis, showing that in two-thirds of cases the first cancer-driving mutation had been acquired before the age of 20—more than 50 years before diagnosis.

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Two thirds of the women who developed acute myeloid leukemia had acquired the first mutation that would drive the disease before the age of 20. The finding opens a way to identify the most at-risk people and, one day, try to stop their evolution.

·Madrid, Spain
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Serial blood samples reveal that acute myeloid leukemia begins to develop half a century before diagnosis, according to a Cambridge study. The entry Leukaemia decades before diagnosis: Cambridge finds the first mutation in children under 20 years of age aparece primero en Merca2.

A study has revealed that a significant number of patients diagnosed with acute myeloid leukemia (AML) in their 70s already possessed the first gene mutation, which serves as the seed of cancer, before the age of 20. The study confirmed that changes in blood cells began decades before the leukemia was discovered, and that the rate of cell proliferation accelerated rapidly after multiple mutations accumulated. According to Medical Express on th…

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Medical Xpress broke the news in Douglas, United Kingdom on Wednesday, November 11, 2026.
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