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Tailoring lipid-polymer hybrid nanoparticles as smart nanocarriers for entacapone delivery for managing Parkinson’s disease
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Tailoring lipid-polymer hybrid nanoparticles as smart nanocarriers for entacapone delivery for managing Parkinson’s disease
Abstract Entacapone is a catechol-O-methyltransferase (COMT) inhibitor, widely used for the symptomatic treatment of Parkinson’s disease. However, it presents setbacks associated with a short half-life and a poor blood-brain barrier permeability. In order to surpass these limitations, entacapone was encapsulated in lipid-polymer hybrid nanoparticles (LPHNPs) functionalized with vitamin E (TPGS), using different liquid lipids as olive oil and coc…
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