US EditionSuper agers' resilience against Alzheimer's disease linked to protective gene variant
Super agers are 68% less likely to carry APOE-ε4 and 28% more likely to carry protective APOE-ε2 compared to cognitively normal peers, Vanderbilt researchers found.
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5 Articles
Super agers' resilience against Alzheimer's disease linked to protective gene variant
The gene variant posing the greatest genetic risk of late-onset Alzheimer's disease (AD) is called APOE-ε4. A different variant of the same gene, APOE-ε2, is thought to confer protection against AD.
Study finds so-called super agers tend to have at least two key genetic advantages; A pair of Alzheimer's risk genes were tracked in the largest study of super agers to date.
The gene variant posing the greatest genetic risk of late-onset Alzheimer's disease (AD) is called APOE-ε4. A different variant of the same gene, APOE-ε2, is thought to confer protection against AD.
Study finds super agers show lower Alzheimer’s genetic risk
A large new study suggests that so-called super agers — adults 80 and older with memory performance comparable to people decades younger — tend to carry fewer genetic risk factors for Alzheimer’s disease and more of the variants believed to offer protection. Researchers reported Jan. 16 in Alzheimer’s & Dementia, the journal of the Alzheimer’s Association, that super agers were significantly less likely to carry APOE-ε4, the gene variant associa…
Mundo, 19 Jan 2026 (ATB Digital) .- A study that has not yet been peer-reviewed shows that the APOE gene is involved in cognitive loss in advanced ages. Getting to an advanced age with full physical and mental abilities is an increasingly common rarity. When it comes to caring for the body there are more and more studies that indicate what are the most efficient ways to stay agile and strong. But when it comes to cognitive performance, researche…
APOE an Under-Recognized Alzheimer’s Disease Target?
A large genetic study highlights APOE as a key contributor to Alzheimer’s Disease risk, raising questions about the field’s laser focus on amyloid and tau. Medscape Medical News Source link : https://www.medscape.com/viewarticle/apoe-gene-under-recognized-alzheimers-disease-therapeutic-2026a10001ps?src=rss Author : Publish date : 2026-01-19 09:23:00 Copyright for syndicated content belongs to the linked Source. The post APOE an Under-Recognized …
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