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Artificial Sweetener Could Impact Cancer Treatment

ALLEGHENY COUNTY, PENNSYLVANIA, JUL 31 – High sucralose consumption disrupts gut bacteria that degrade arginine, essential for T cell function, reducing immunotherapy success in melanoma and lung cancer patients, study shows.

  • A 2025 study conducted by researchers affiliated with Pittsburgh’s medical institutions revealed that sucralose consumption reduces the effectiveness of cancer immunotherapy.
  • They found sucralose changed the gut microbiome, reducing arginine levels essential for T cell function, leading to poorer immunotherapy response in melanoma and lung cancer patients.
  • Mouse models confirmed sucralose disrupted gut bacteria, impaired immunotherapy by lowering arginine, and tumors grew larger, but arginine supplementation restored treatment effectiveness.
  • Participants who consumed lower amounts of sucralose experienced 5 to 11 months longer periods without cancer progression, and Overacre noted that even minimal sucralose intake correlated with poorer responses to immunotherapy.
  • Researchers propose clinical trials testing arginine supplements and reducing sucralose in diets to improve outcomes, noting drastic diet changes may not be realistic for patients.
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Medical Xpress broke the news in on Thursday, July 31, 2025.
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