US EditionStudy Finds Five Genetic Risk Factors Shared Across 14 Mental Health Disorders
Analysis of over one million genomes reveals 14 psychiatric disorders cluster into five genetic groups with 238 shared genomic regions, explaining frequent multiple diagnoses.
- On December 10, researchers led by Andrew D. Grotzinger published in Nature the largest cross-disorder genetic analysis, grouping 14 psychiatric disorders into five genomic categories using data from over 6 million individuals.
- Motivated by high comorbidity, Grotzinger and colleagues aggregated genomic data from more than one million individuals with disorders and millions of healthy controls to explore biological explanations beyond psychiatric diagnostic manuals.
- Data analysis revealed 428 shared variants and 101 hotspots, identifying 238 genomic regions and a chromosome 11 locus linked to dopamine signalling genes across eight disorders.
- Researchers say the findings could point to shared treatment targets as five core genomic factors account for two-thirds of inherited risk and explain diagnoses in patients diagnosed with multiple conditions.
- The team warned the analysis is skewed toward people of European ancestry and urged caution, with Kendler noting, `Psychiatry is the only medical specialty with no definitive laboratory tests...` and researchers highlighting embryo screening and clinical application concerns.
28 Articles
28 Articles
Depression, anxiety and PTSD have same genetic roots – what it means for treatment
This is Everyday Science with Clare Wilson, a subscriber-only newsletter from The i Paper. If you’d like to get this direct to your inbox every week, you can sign up here. Hello, and welcome back to Everyday Science. What are currently seen as three separate mental health conditions – depression, anxiety and post-traumatic stress disorder (PTSD) – could really be different aspects of the same underlying brain disorder. In fact, the 14 most commo…
Psychiatric disorders share genetic roots, explains why some have multiple diagnoses: VCU study
A new study from Virginia Commonwealth University (VCU) shows 14 psychiatric disorders share genetic roots, which can explain why some people have multiple diagnoses.
Shared genetic roots of 14 psychiatric disorders revealed
Researchers from the Psychiatric Genomics Consortium (PGC) report that most genetic influences on mental illness are shared across diagnostic categories, revealing a more interconnected biological landscape than traditional classifications suggest.
Genetic overlap of 14 psychiatric disorders explains why patients often have multiple diagnoses
An international collective of researchers is delivering new insights into why having multiple psychiatric disorders is the norm rather than the exception. In a study published today in the journal Nature, the team provides the largest and most detailed analysis to date on the genetic roots shared among 14 conditions.
Coverage Details
Bias Distribution
- 69% of the sources are Center
Factuality
To view factuality data please Upgrade to Premium
