US EditionStudy finds cancer cells boost energy to survive mechanical stress and DNA damage
BARCELONA, JUL 30 – Cancer cells increase energy by 60% within seconds under compression to repair DNA and survive mechanical stress, aiding their invasive and metastatic behavior, researchers found.
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9 Articles
Study finds cancer cells boost energy to survive mechanical stress and DNA damage
Cancer cells mount an instant, energy‑rich response to being physically squeezed, according to a study published in the journal Nature Communications. The surge of energy is the first reported instance of a defensive mechanism that helps cells repair DNA damage and survive the crowded environments of the human body.
Confined Cancer Cells Undergo Nuclear ATP Surge, Unlocks Therapy Target
Cancer cells undergo physically constraining processes, such as intravasation, extravasation, and tissue infiltration, that lead to acute mechanical stress. How mechanical confinement rewires the localization of organelles and affects cellular metabolism is largely unknown. Understanding this mechanism could lead to new strategies to control cancer metastasis. In a new study published in Nature Communications titled, “Mitochondria-derived nucle…
Innsbruck – Cancer cells react to mechanical pressure with an energy boost that helps them repair DNA damage and survive in cramped environments of the body. A team led by Verena Ruprecht from the University of Innsbruck and Sara Sdelci from the Centre for Genomic Regulation (CRG) in Barcelona has described this protective mechanism of cancer cells for the first time. [...]
As detailed, this finding helps explain how tumor cells overcome genuine mechanical “obstacles”—from crawling through the tumor microenvironment or entering porous blood vessels to supporting the circulatory stream—and opens a window for the development of strategies that immobilize cancer cells before they expand. The team of the Centre for Genomic Regulation (CRG) of Barcelona made the discovery with a specialized microscope capable of compres…
Researchers from Innsbruck were able to show how cell power plants can combat metastatic cells and invasive tumors.
Pressure damage is repaired with a lot of energy, as experts from Innsbruck noted. They observed that a ring was created from "cell power plants", and derive from it a new possibility of cancer control
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