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Study elucidates mechanism connecting ER membrane remodeling to pyroptosis in cancer cells

Summary by News Medical
Pyroptosis, a highly inflammatory type of programmed cell death, has garnered attention for its potential in cancer treatment.

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Study elucidates mechanism connecting ER membrane remodeling to pyroptosis in cancer cells

Pyroptosis, a highly inflammatory type of programmed cell death, has garnered attention for its potential in cancer treatment.

·United States
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NewswiseNewswise

Targeting ER dynamics: a novel strategy for antitumor immunity

A groundbreaking study has revealed that reticulon-4 (RTN4), a protein involved in regulating the endoplasmic reticulum (ER) membrane curvature, plays a pivotal role in pyroptosis, a form of programmed cell death. The research demonstrates how manipulating RTN4 can trigger pyroptosis in cancer cells, enhancing antitumor immune responses. By targeting RTN4, the ER membrane undergoes significant remodeling, leading to the formation of the typical …

·Charlottesville, United States
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Newswise broke the news in Charlottesville, United States on Monday, March 3, 2025.
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