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Stopping weight loss drug can lead to weight regain, study finds

Regaining weight after stopping a GLP-1 medication is a commonly reported side effect — but going off the drug may also result in the loss of other health improvements, as well. New clinical trial analysis of the SURMOUNT-4 trial found that a majority of people who stopped taking tirzepatide (marketed for weight loss under the brand name Zepbound ) not only gained back at least 25 percent of weight lost on the drug — they also experienced a sign…

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The Independent broke the news in London, United Kingdom on Tuesday, November 25, 2025.
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