Tome Bio founders wrangle ‘jumping genes’ to create new programmable gene insertion tool

Tome Bio founders wrangle ‘jumping genes’ to create new programmable gene insertion tool

Two Boston scientists say they have developed a new gene editing tool based on mysterious "jumping genes" known as retrotransposons, which can copy and paste themselves to hop around the genome. While retrotransposons have tantalized ...

STITCHR retrotransposon-based gene editor enables large, scarless DNA insertions

A novel gene editing tool named STITCHR, developed at Mass General Brigham and collaborating institutions, overcomes central limitations of current technologies by enabling the scarless insertion of entire genes or large DNA fragments up to 12.7 kb. Based on reprogrammed retrotransposon activity guided by a Cas9 nickase and using RNA templates, STITCHR shows potential for… The post Meet STITCHR, the retrotransposon-based gene editor that enables…