US EditionScientists Discover Brain-Penetrating Compounds That May Calm Alzheimer’s-Linked Inflammation
3 Articles
3 Articles
Scientists Discover Brain-Penetrating Compounds That May Calm Alzheimer’s-Linked Inflammation
Researchers have created a targeted compound that blocks an enzyme linked to inflammation in individuals with a genetic predisposition to Alzheimer’s disease, while still maintaining normal brain activity and successfully passing through the blood-brain barrier. Scientists at the University of So
Researchers at the University of Southern California (USC) have announced the development of a series of novel compounds that selectively inhibit an enzyme associated with brain inflammation in carriers of the gene APOE4, considered the most significant genetic risk factor for Alzheimer's disease. The findings, published in Nature's npj Drug Discovery journal, may form the basis for a new therapeutic approach - one that doesn't focus on amyloid …
Small Molecule Targets Enzyme Driving Inflammation in Alzheimer's Disease
Scientists at the University of Southern California have identified an enzyme central to inflammatory lipid signaling called calcium-dependent phospholipase A2 (cPLA2) that plays a central role in brain inflammation associated with Alzheimer’s disease (AD) among people who carry the APOE4 gene. The research was published in the Nature publication npj Drug Discovery. “In this study, we identified compounds that act selectively on cPLA2, with mini…
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