US EditionShc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development
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Shc1 cooperates with Frs2 and Shp2 to recruit Grb2 in FGF-induced lens development
Fibroblast growth factor (FGF) signaling elicits multiple downstream pathways, most notably the Ras/MAPK cascade facilitated by the adaptor protein Grb2. However, the mechanism by which Grb2 is recruited to the FGF signaling complex remains unresolved. Here, we showed that genetic ablation of FGF signaling prevented murine lens induction by disrupting transcriptional regulation and actin cytoskeletal arrangements, which could be reproduced by de…
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