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Scientists use AI facial analysis to predict cancer survival outcomes

  • Researchers at Mass General Brigham developed FaceAge, an AI model using facial photos to predict biological age and cancer survival outcomes, reported in 2025.
  • The algorithm was developed using a dataset of 58,851 images of presumably healthy adults over 60 and subsequently evaluated on 6,196 cancer patients whose photographs were captured prior to beginning radiotherapy.
  • FaceAge revealed that cancer patients tend to have a biological age nearly five years greater than their actual age, and elevated FaceAge scores were linked to poorer survival outcomes regardless of patients’ age, gender, or type of tumor.
  • Doctors' predictions of six-month survival improved by 20% with FaceAge data, though initial accuracy was little better than chance, and the AI focuses on subtle facial features unlike humans.
  • Researchers are training a second-generation model with 20,000 patients and plan a public portal for further validation, emphasizing ethical use to benefit patients amid concerns about AI bias.
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AI tool uses selfies to predict biological age and cancer survival

Doctors often start exams with the so-called "eyeball test" -- a snap judgment about whether the patient appears older or younger than their age, which can influence key medical decisions.

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WBUR broke the news in Boston, United States on Thursday, May 8, 2025.
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