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Scientists unravel how citrin deficiency can trigger fat buildup in the liver even in lean individuals

Researchers found that accumulation of G3P activates fat synthesis and hormone FGF21, explaining fatty liver in lean individuals and offering new treatment options for MASLD.

Summary by News Medical
Scientists at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the U.S. and a leading research center for diabetes and other life-threatening illnesses, have unraveled how citrin deficiency (CD), a rare genetic disorder that prevents the liver from converting food into energy efficiently, can trigger fat buildup in the liver - even in lean individuals.

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News Medical broke the news in United States on Thursday, December 18, 2025.
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