Scientists Reveals How Cancer-Causing P53 Mutations Remain Invisible to the Immune System
8 Articles
8 Articles
Making invisible cancers visible: A new route to turn 'cold' tumors 'hot'
One of the biggest challenges in cancer immunotherapy may not be that immune cells are too weak, but that some tumors give them too little to see. New research from Dana-Farber Cancer Institute scientists reveals how cancers carrying mutations in the p53 tumor-suppressor protein can hide those mutations from T cells and suggests a therapeutic countermeasure: Change what the cancer displays on its surface so the immune system can recognize the tu…
Mutations in the tumor suppressor p53 could provide ideal targets for T cells, but cancer cells do not show many of these peptides at all stable on their surface. Experiments show several camouflage mechanisms, including the destruction of a p53 peptide by the enzyme ERAP1. Blocking this enzyme restored the target in cell experiments, but the strategy has not yet been clinically tested. Boston [...] The article New approach makes invisible cance…
Thüringer Allgemeine
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