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Scientists Discover Brain Spot that Drives Risk-Taking Decisions

Six epilepsy patients helped researchers identify two orbitofrontal patches that drive risk-taking or avoidance decisions about half a second before action.

  • On Tuesday, UCSF and Berkeley researchers published findings in Nature Neuroscience identifying two distinct brain circuits in the OFC that dictate risk-taking and avoidance, allowing scientists to predict choices 500 milliseconds before action.
  • Researchers monitored six patients playing an immersive video game, revealing the brain oscillates between two extremes like a switch rather than accumulating evidence like a slowly turning dial.
  • Two neighboring regions operate in inverse synchronization: The Medial Orbital Sulcus surges when players confront risk, while The Lateral Orbitofrontal Patch two centimeters away spikes when opting to play it safe.
  • Identifying these specific 'go' and 'stop' zones could allow for millimeter-precision neuromodulation, as targeting the OFC previously yielded mixed outcomes when clinicians treated the region as a monolith.
  • Clara Starkweather, MD, PhD, a neurosurgery chief resident at UCSF, aims to move beyond subjective mood scores by developing objective, measurable signatures of brain risk-weighing to target psychiatric treatments.
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If you weigh between possible gain and imminent loss, the orbitofrontal cortex shows two spatially separated, opposite activity patterns. Direct brain derivations in six patients show that these patterns change quickly before a decision is made between approach and avoidance and are increasingly aligned to the later choice about half a second before the reaction. San Francisco (U.S.A.). In case of risky decisions, the brain has to weigh possible…

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Medical Xpress broke the news in Douglas, United Kingdom on Tuesday, September 15, 2026.
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