Scientists map activation of prostaglandin E₂ receptor EP1 at atomic level

Scientists map activation of prostaglandin E₂ receptor EP1 at atomic level

Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes through four G protein-coupled receptor (GPCR) subtypes: EP1–EP4. While the high-resolution structures of EP2, EP3 and EP4 have been resolved, EP1 remained structurally uncharacterized due to its intrinsic instability, hindering detailed understanding of its Gq-mediated signaling.