Yeast Cell Division 'Pacemaker' Found Inside Nucleus, Not Outside as Once Believed

Yeast cell division 'pacemaker' found inside nucleus, not outside as once believed

Researchers at the Francis Crick Institute have shown that the "pacemaker" controlling yeast cell division lies inside the nucleus rather than outside it, as previously thought. Having the pacemaker in the same compartment as the cell's DNA helps keep the genome stable.

Change of venue: fission-yeast cell-division cues actually initiate in the nucleus

In yeast, the CDK and cyclin proteins that drive cell division activate first in the nucleus — a different location in the cell from where was previously thought. In yeast, the CDK and cyclin proteins that drive cell division activate first in the nucleus — a different location in the cell from where was previously thought.

Cyclin-Dependent Kinase Orchestrates Mitosis Timing

In the intricate symphony of cell division, timing and localization of molecular regulators are paramount. New insights into the spatiotemporal orchestration of mitosis by cyclin-dependent kinase (CDK) challenge longstanding conceptions about where and how CDK activation initiates within the cell. Contrary to prevailing models positing that mitotic CDK activation begins at the cytoplasm’s centrosome or spindle pole body (SPB), recent findings re…

Scientists Identify Cell Nucleus as the Pacemaker of Cell Division

Researchers at the leading Francis Crick Institute have unveiled groundbreaking insights into the fundamental mechanisms governing cell division, challenging longstanding assumptions and reshaping our understanding of cellular biology. Their latest study reveals that the “pacemaker” orchestrating the timing of cell division is not located in the cytoplasm as was traditionally believed, but rather within the nucleus—the very heart of the cell hou…

Researchers show that the cell nucleus is the pacemaker for cell division

Researchers at the Francis Crick Institute have shown that the 'pacemaker' controlling yeast cell division lies inside the nucleus rather than outside it, as previously thought. Having the pacemaker in the same compartment as the cell's DNA helps keep the genome stable.