US EditionUsing Cancer Drugs for Alzheimer’s Disease — and More Health Headlines
SAN FRANCISCO, CALIFORNIA, JUL 21 – Two FDA-approved cancer drugs improved memory and reduced brain damage in Alzheimer's mice, with patient data showing up to 80% lower Alzheimer’s risk, researchers said.
- On July 21, 2025, researchers at UCSF and Gladstone Institutes published findings showing memory improvements and reduced brain damage in a mouse model of Alzheimer’s.
- Given the complexity of Alzheimer’s and the high cost and time required for new therapies, researchers turned to repurposing existing medications.
- Using computational and experimental tests, the scientists screened over 1,300 FDA-approved drugs, finding ten that reversed Alzheimer’s gene signatures, and the combination therapy undid disease-related gene expression in neurons and glia while reducing toxic clumps and degeneration.
- Dr. Huang said it's `so exciting to see the validation of the computational data in a widely used Alzheimer's mouse model`, noting that the multi-target strategy may outperform current treatments but requires human trials.
- Looking ahead, researchers plan to conduct clinical trials to assess the combination’s safety and efficacy in Alzheimer’s patients, given translation challenges from mice to humans.
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Using cancer drugs for Alzheimer’s disease — and more health headlines
Medical Watch Digest for July 21 Cancer drugs & dementia treatment Two successful cancer drugs appear to have a new use, fighting memory loss. University of California San Francisco doctors tested 1,300 approved cancer medications. They found a combination of two drugs have power against the most common form of dementia. They work by reversing the changes that occur in the brain during Alzheimer’s. The FDA approved medications reduced brain dege…
Memory Restored? Cancer Drug Combo Reverses Alzheimer’s In Mice
Two cancer medications already on pharmacy shelves might hold the key to treating Alzheimer's disease, and early results suggest they work better together than apart. The post Memory Restored? Cancer Drug Combo Reverses Alzheimer’s In Mice appeared first on Study Finds.
Combination of two cancer drugs could treat the most common form of dementia
A study comparing the gene expression signature of Alzheimer's disease with those elicited by 1,300 approved drugs found a combination of two cancer medications that could treat the most common form of dementia.
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