TNF Hampers Intestinal Tissue Repair in Colitis by Restricting IL-22 Bioavailability

TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability

Successful treatment of chronic inflammatory diseases integrates both the cessation of inflammation and the induction of adequate tissue repair processes. Strikingly, targeting a single proinflammatory cytokine, tumor necrosis factor (TNF), induces both processes in a relevant cohort of inflammatory bowel disease (IBD) patients. However, the molecular mechanisms underlying intestinal repair following TNF blockade during IBD remain elusive. Using…

Spatial mapping reveals network of cells and genes involved in Crohn's disease complication

Up to half of patients with Crohn's disease, an inflammatory bowel disease, develop a complication called fibrosis, where the gut becomes scarred and obstructed, causing pain and bloating. Currently, the only treatment option for these gut "strictures" is surgery.

Innate immunity of the gut epithelium: Blowing in the WNT?

Intestinal epithelial cells need to be able to launch a quick and adequate immune response against pathogens, while tolerating commensals. This delica…

Study: Crohn’s Disease Investigational Treatment Shows Potential for Achieving Remission

Cedars-Sinai investigators have developed an investigational therapy that brought a significant number of patients with moderate to severe Crohn's disease into remission, according to a new study published in The Lancet Gastroenterology & Hepatology.

Fecal Transplant for Ulcerative Colitis (UC): Does It Work?

If you have ulcerative colitis (UC), you may wish you could swap out your entire digestive system. There's a potential treatment that may come close: someone else's fecal matter. Often called fecal microbiota transplants (FMT), this procedure involves specially prepared fecal samples from a healthy donor — one without UC or other digestive conditions — which is introduced into the large intestine (colon) of someone with an inflammatory disease l…