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SACHI Trial Results: Savolitinib-Osimertinib Combo Improves PFS in MET-Amplified EGFR-Mutated NSCLC - ILCN.org (ILCN/WCLC)

MET amplification is a key resistance mechanism in more than 20% of pretreated EGFR-mutant non-small cell lung cancer (NSCLC) cases. It’s also tied to early disease progression and poor prognosis. Shun Lu, MD, PhD Biomarker-guided treatment options after progression on EGFR-tyrosine kinase inhibitor (TKI) therapy remain limited. Until recently, no randomized study has addressed the role of targeted therapies for MET-amplification in this clinic…
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ILCN.org (ILCN/WCLC) broke the news in on Tuesday, July 8, 2025.
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