US EditionRudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development
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Rudhira-mediated microtubule stability controls TGFβ signaling during mouse vascular development
The transforming growth factor β (TGFβ) signaling pathway is critical for survival, proliferation, and cell migration, and is tightly regulated during cardiovascular development. Smads, key effectors of TGFβ signaling, are sequestered by microtubules (MTs) and need to be released for pathway function. Independently, TGFβ signaling also stabilizes MTs. Molecular details and the in vivo relevance of this cross-regulation remain unclear, understand…
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