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Roche's Obesity Drug Shows Promise But Trails GLP-1 Giants Novo Nordisk, Eli Lilly - Roche Holding (OTC:RHHBY)

Phase 2 ZUPREME-1 trial showed petrelintide led to significant weight loss with low discontinuation and a favorable safety profile in 493 obese participants, Zealand said.

Summary by Benzinga
Roche Group AG’s (OTC:RHHBY) obesity drug push faces stiff competition after Genentech, a unit of Roche, reported Phase 2 results showing up to 10.7% weight loss—below expectations and lagging leading treatments from Novo Nordisk A/S (NYSE:NVO) and Eli Lilly and Co. (NYSE:LLY). Genentech on Thursday shared topline results from the Phase 2 ZUPREME-1 trial evaluating petrelintide versus placebo in 493 obese participants (mean BMI of 37 kg/m²). In …

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The Danish biotech collapses on the Stock Exchange after the disappointing data of its petrelintide and brings its Swiss partner into its fall.

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Ekstra Bladet broke the news in Denmark on Friday, March 6, 2026.
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