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News from Clinical Trials Arena

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Top Clinical Trials Arena News

Johnson & Johnson unveils first-in-human results for pasritamig, showing early anti-tumor activity in prostate cancer
United States · United States

Johnson & Johnson unveils first-in-human results for pasritamig, showing early anti-tumor activity in prostate cancer

79% Center coverage: 14 sources
Pasritamig, a first-in-class bispecific T-cell-engaging antibody, shows potential in mCRPC with outpatient dosing designed for the community settingSee the Story
Precision Pfizer Drug Leads to ‘Unprecedented’ Survival in Colorectal Cancer, Data at ASCO Show
Cancer

Precision Pfizer Drug Leads to ‘Unprecedented’ Survival in Colorectal Cancer, Data at ASCO Show

60% Center coverage: 5 sources
Pfizer drug Braftovi achieved statistically significant and clinically meaningful improvement in overall survival for colorectal cancer patients in a Phase 3 clinical trial. The results will be presented Friday during the annual meeting of the American Society of Clinical Oncology. The post Precision Pfizer Drug Leads to ‘Unprecedented’ Survival in Colorectal Cancer, Data at ASCO Show appeared first on MedCity News.See the Story
Adjuvant Cemiplimab Improves Disease-Free Survival in High-Risk Cutaneous SCC

Adjuvant Cemiplimab Improves Disease-Free Survival in High-Risk Cutaneous SCC

100% Center coverage: 1 sources
(MedPage Today) -- CHICAGO -- Adjuvant cemiplimab (Libtayo) significantly improved disease-free survival (DFS) compared with placebo in patients at high risk of recurrence of cutaneous squamous-cell carcinoma (SCC), a phase III randomized trial...See the Story

Introducing the Naval Technology Excellence Awards 2025

The 2025 Naval Technology Excellence Awards are open for submissions. Download our Research Guide for more detailsThe post Introducing the Naval Technology Excellence Awards 2025 appeared first on Naval Technology.U.S. NavySee the Story

A Generative AI-Discovered TNIK Inhibitor for Idiopathic Pulmonary Fibrosis: a Randomized Phase 2a Trial

100% Center coverage: 1 sources
Despite substantial progress in artificial intelligence (AI) for generative chemistry, few novel AI-discovered or AI-designed drugs have reached human clinical trials. Here we present the results of the first phase 2a multicenter, double-blind, randomized, placebo-controlled trial testing the safety and efficacy of rentosertib (formerly ISM001-055), a first-in-class AI-generated small-molecule inhibitor of TNIK, a first-in-class target in idiopa…Artificial IntelligenceSee the Story

Arrowhead commences dosing in Phase I/IIa obesity treatment trial

Arrowhead Pharmaceuticals has dosed the first participant in the Phase I/IIa AROALK7-1001 trial of ARO-ALK7.The post Arrowhead commences dosing in Phase I/IIa obesity treatment trial appeared first on Clinical Trials Arena.Louisa County · Louisa CountySee the Story

ASCO25: Focus V fails to show superiority over bevacizumab in first-line metastatic CRC

Focus V has shown limited PFS benefit, a high incidence of AEs, and no demonstrated improvement in overall survival.The post ASCO25: Focus V fails to show superiority over bevacizumab in first-line metastatic CRC appeared first on Clinical Trials Arena.Read Article

The Predictive Model for Risk of Chemotherapy-Induced Thrombocytopenia Based on Antineoplastic Drugs for Solid Tumors in Eastern China

100% Center coverage: 1 sources
Chemotherapy-related thrombocytopenia (CIT) is a significant adverse event during chemotherapy, which can lead to reduced relative dose intensity, increased risk of serious bleeding and additional medical expenditure. Herein, we aimed to develop and validate a predictive nomogram model for prediction of CIT in patients with solid tumor. From Jun 1, 2018 to Sep 9, 2021, a total of 1541 patients who received 5750 cycles of chemotherapy were retros…AmgenSee the Story

ASCO25: Trodelvy and Keytruda to become new standard of care for frontline TNBC

At the American Society of Clinical Oncology (ASCO) Annual Meeting, held 30 May-3 June 2025, primary results were presented from the ASCENT-04/KEYNOTE-D19 study investigating Gilead’s Trodelvy, a trophoblast cell surface antigen 2 (TROP 2)-directed antibody-drug conjugate (ADC), in combination with Keytruda (pembrolizumab), versus standard-of-care (SOC) chemotherapy plus pembrolizumab in patients with PD-L1-positive (CPS ≥10) metastatic triple-n…Breast Cancer · ChicagoRead Article

ASCO 2025: AstraZeneca’s novel trial design for camizestrant pays off in breast cancer

100% Right coverage: 1 sources
Camizestrant will reach blockbuster status in 2030 with total sales worth $1.1 billion, according to GlobalData’s analyst consensus forecast.The post ASCO 2025: AstraZeneca’s novel trial design for camizestrant pays off in breast cancer appeared first on Clinical Trials Arena.DietSee the Story

ASCO25: Novartis hopes Scemblix becomes new standard for CML-CP

The ASC4FIRST study found Novartis' Scemblix to be more effective than standard-of-care tyrosine kinase inhibitors.The post ASCO25: Novartis hopes Scemblix becomes new standard for CML-CP appeared first on Clinical Trials Arena.Read Article

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