Neurofilaments Can Differentiate ALS Subgroups and ALS From Common Diagnostic Mimics

Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics

Delayed diagnosis and misdiagnosis are frequent in people with amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease (MND). Neurofilament light chain (NFL) and phosphorylated neurofilament heavy chain (pNFH) are elevated in ALS patients. We retrospectively quantified cerebrospinal fluid (CSF) NFL, CSF pNFH and plasma NFL in stored samples that were collected at the diagnostic work-up of ALS patients (n = 234), ALS mim…

Respiratory Training Shows Modest Benefits in ALS

TOPLINE: Respiratory muscle training moderately improved lung function, especially respiratory muscle strength, in patients with amyotrophic lateral sclerosis (ALS) compared with no intervention or sham training. METHODOLOGY: Researchers conducted a meta-analysis to assess the effect of respiratory muscle training on lung function and respiratory muscle strength in patients with ALS. They gathered data from five […] The post Respiratory Training…