Breakdown of Immune Cells' Interaction Is Key Driver in Aging, Study Finds

Researchers identify immune cell receptor that drives organ aging process

We may age at different rates, but none of us escapes aging. A study in mice and in human cells by Stanford Medicine researchers pins much of the blame on a particular type of immune cell's increased inability, with advancing age, to gobble up another immune cell type.

Breakdown of immune cells' interaction is key driver in aging, study finds

We may age at different rates, but none of us escapes aging. A study in mice and human cells by Stanford Medicine researchers pins much of the blame on a particular type of immune cell's increasing inability, with advancing age, to gobble up another immune cell type.

Organ Aging Linked to Breakdown in Immune Cell Interaction and Senescent Neutrophil Clearance

We may age at different rates, but none of us escapes aging. A study in mice and in human cells by Stanford Medicine researchers has linked organ aging to the increased inability—with advancing age—of tissue resident macrophage (TRM) immune cells to clear aged neutrophils, another type of immune cell. The study found that these TRMs appear to be central coordinators of age-related organ decline. Blocking a single receptor, EP2, on these cells pr…

Breakdown in Immune Cell Interaction Linked to Aging - Archyworldys

Stanford Medicine researchers have identified that tissue-resident macrophages lose their ability to clear senescent, or “zombie,” neutrophils due to the buildup of…

Study Identifies Immune Cell Failures as Aging Drivers

We may age at different rates, but none of us escapes aging.

Stanford Finds Blocking Single Receptor Restores Youth in Mice

Stanford Medicine researchers discovered that blocking a single pro-inflammatory receptor on specific immune cells reverses multi-organ aging in mice. The study, published in the journal Science, targets tissue-resident macrophages—immune cells that act as cellular clean-up crews. These cells lose their ability to clear expiring white blood cells as the body grows older, triggering systemic chronic inflammation.The research team focused on the i…