RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

To uncover tumor suppressors in human HCC, scientists performed a genome-wide CRISPR/Cas9-based screening of primary human hepatocytes with MYC and TP53R249S overexpression is performed in xenografts. [Advanced Science] Full Article