US EditionRegulating the DNA Damage Response as a Treatment for Synucleinopathies
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Regulating the DNA Damage Response as a Treatment for Synucleinopathies
Synucleinopathies are neurodegenerative conditions characterized by the aggregation of misfolded α-synuclein, a form of protein aggregation that drives much of the pathology of these diseases. The most prominent synucleinopathy is Parkinson's disease, but it may well be that α-synuclein plays a role in the aging of the brain more generally. Synucleinopathies are exaggerated versions of a damaging process that operates to some degree in every old…
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