US EditionRegCell Scientific Founder and Board Member Dr. Shimon Sakaguchi Awarded Nobel Prize in Physiology or Medicine
Their discovery of regulatory T-cells revealed how the immune system prevents self-attack, with the Foxp3 gene playing a key role, advancing autoimmune disease research.
- On Oct. 9, 2025, Dr. Shimon Sakaguchi, Distinguished Professor of Osaka University and Professor Emeritus of Kyoto University, received the 2025 Nobel Prize in Physiology or Medicine for work on regulatory T-cells, RegCell, Inc. announced.
- After ten years of work, Sakaguchi published his 1995 paper on regulatory T-cells, inspired by neonatal mouse experiments at Aichi Cancer Center Research Institute, Nagoya, despite 1980s funding scepticism.
- T-Regs act to prevent autoimmunity and their malfunction can cause autoimmune diseases, while researchers now link Foxp3 gene-regulated T-regs to cancer, organ transplantation, and neurodegenerative diseases.
- CEO Dr. Michael McCullar said, `We are deeply honored to count on Dr. Sakaguchi as a scientific founder of RegCell and among our board members`, and Sakaguchi hopes cancer immunotherapy trials can reach patients, reflecting optimism for future therapies.
- Looking ahead, the discovery positions clinical research and future therapies to target T-reg–mediated inflammation, potentially reversing autoimmune disorders and aiding organ transplantation recipients.
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RegCell Scientific Founder and Board Member Dr. Shimon Sakaguchi Awarded Nobel Prize in Physiology or Medicine
EMERYVILLE, Calif., Oct. 9, 2025 /PRNewswire/ -- RegCell, Inc. a biotechnology company developing first-in-class therapies for autoimmune diseases and transplantation with its epigenetic reprogramming platform leveraging the natural biology of regulatory T cells (Tregs), proudly announced that Dr. Shimon Sakaguchi,…
Nobel laureate Shimon Sakaguchi on his immune system breakthrough – and the treatments he hopes it will unlock
Back in the 1980s, when Shimon Sakaguchi was a young researcher in immunology, he found it difficult to get his research funded. Now, his pioneering work which explains how our immune system knows when and what to attack, has won him a Nobel prize. Sakaguchi, along with American researchers Mary Brunkow and Fred Ramsdell, were jointly awarded the 2025 Nobel prize in physiology or medicine for their work on regulatory T-cells, known as T-regs for…
SHRO's congrats to the winners of the 2025 Nobel Prize in Physiology or Medicine - Sbarro Health Research Organization
Congratulations to the winners of the 2025 Nobel Prize in Physiology or Medicine!On behalf of the Sbarro Health Research Organization – SHRO Italy, we congratulate Mary E. Brunkow, Frederick J. (Fred) Ramsdell, and Shimon Sakaguchi, awarded the Nobel Prize “for discoveries on peripheral immune tolerance” and on the role of regulatory T cells (Tregs) in keeping the immune system in balance. Thanks to these discoveries, oncologists have: gained a …
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