Rational development of solubilizing formulations: mechanistic and data-driven approaches to excipient selection

Rational development of solubilizing formulations: mechanistic and data-driven approaches to excipient selection

Summary Background: Pharmaceutical excipients have traditionally been regarded as inactive components of dosage forms. However, in bioenabling formulations, they are essential to achieving sufficient systemic exposure for therapeutic efficacy. Excipients represent a chemically diverse and structurally undefined group. Together with the structural diversity of drugs, this often necessitates trial-and-error approaches during formulation developmen…