Prothrombin Complex Concentrate Effective in Cardiac Surgery

Trial results open door to frozen plasma alternative for bleeding management in cardiac surgery - Cardiovascular News

Keyvan Karkouti Four-factor prothrombin complex concentrate (4F-PCC)—a shelf-stable medication containing freeze-dried clotting factors—has been shown to be significantly more effective in addressing severe bleeding during cardiac surgery compared to the current standard of care, frozen plasma. This is the headline finding from FARES-II, a phase 3, randomised, active-control study, comparing the two approaches in adult cardiac surgery patients w…

Prothrombin Complex Concentrate Effective in Cardiac Surgery

A major clinical trial finds prothrombin complex concentrate (PCC) is safer and more effective than frozen plasma for treating bleeding during cardiac surgery. Discover key findings and implications for surgical care.