Protein Condensation Diseases: Therapeutic Opportunities

Protein condensation diseases: therapeutic opportunities

Condensed states of proteins, including liquid-like membraneless organelles and solid-like aggregates, contribute in fundamental ways to the organisation and function of the cell. Perturbations of these states can lead to a variety of diseases through mechanisms that we are now beginning to understand. We define protein condensation diseases as conditions caused by the disruption of the normal behaviour of the condensed states of proteins. We an…

Protein discovery could reverse Huntington’s disease damage, study finds

In the complex world of neuroscience, Huntington’s disease remains a cruel mystery. It slowly strips away a person’s ability to think and move, yet scientists still don’t fully understand why. Researchers at the University at Buffalo have spent over ten years trying to unravel that mystery. Now, they’ve uncovered two tiny but powerful proteins that may hold the key to stopping the disease before it causes irreversible damage. What Happens in Hun…