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Programmable conjugative CRISPR interference targeting genotoxin in the gut
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1 Articles
Programmable conjugative CRISPR interference targeting genotoxin in the gut
Among microbially derived metabolites that influence host disease, colibactin garners increasing attention for its roles in the rising incidence of early-onset colorectal cancer. Produced by pks⁺ Escherichia coli, colibactin is a potent genotoxin, yet no approved therapeutics directly suppress it...
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