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Position Effect Variegation as a Way to Visualize Age-Related Structural Change of Nuclear DNA

Summary by fightaging.org
Nuclear DNA is surrounded by transcriptional machinery, protein structures that will attempt to transcribe any gene sequence they encounter. Where DNA is compacted into regions of heterochromatin by being spooled onto histones, genes are silenced because their sequences are hidden from transcriptional machinery. Whether a given stretch of DNA is compacted or not is determined by epigenetic mechanisms, largely decorations (such as methyl groups) …
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fightaging.org broke the news in on Thursday, February 12, 2026.
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