Pitt researchers develop a new way to profile pediatric brain tumors

Cancer research needs neuroscience and neuroscientists

The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease progression. Tumors growing within the brain or elsewhere in the body connect with neuronal networks in circuit-specific manners, via neuron-to-cancer synaptic interactions and paracrine crosstalk. Moreover, neural factors govern critical components of the tumor environme…

Pitt researchers develop a new way to profile pediatric brain tumors

Researchers and pediatric neurosurgeons at the University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh developed a new way to profile brain cancers in children, paving the way for improved diagnostics and treatments.

Classifying childhood brain cancers by immune response may improve diagnostics and treatments

Researchers and pediatric neurosurgeons at the University of Pittsburgh School of Medicine and UPMC Children's Hospital of Pittsburgh have developed a new way to profile brain cancers in children, paving the way for improved diagnostics and treatments.

Girl, 2, was diagnosed with brain tumor after mom spotted subtle symptoms that doctors dismissed

Gracelyn Stiffler's mother had to beg for her young daughter to have a CT scan, which went on to reveal that the two-year-old had a mass on her brain

Pediatric Brain Tumor Classification Improves Therapy

Cancer is the rapid proliferation of malignant cells that permeate tissue and cause dysregulation of the body’s daily functions. Many cancers can be

Researchers Predict Paradigm Shift in the Analysis of TILs in Pediatric Brain Tumors

Researchers and pediatric neurosurgeons from the University of Pittsburgh School of Medicine and UPMC Children’s Hospital of Pittsburgh have developed a novel way to generate a detailed immunoprofile of pediatric brain tumors that could lead to more effective, personalized immunotherapies. They focused on the diverse T cell receptor (TCR) repertoire within tumor-infiltrating lymphocytes (TILs), creating what they termed a clonal expansion-activa…