US EditionChinese Surgeons Achieve World’s First Transplant of Genetically Modified Pig Lung Into Brain-Dead Man
The pig lung, genetically modified with six gene edits, functioned without rejection for nine days in a brain-dead patient, advancing xenotransplantation research for lung organ shortages.
- On May 15, 2024 researchers at the First Affiliated Hospital of Guangzhou Medical University transplanted a genetically modified pig left lung into a brain-dead 39-year-old man, as reported in Nature Medicine on Aug. 25.
- Facing a shortage of human donor organs, fewer than 25,000 transplants occurred in 2023 while more than 500,000 Americans have kidney failure; recent years saw xenotransplantation history with gene-edited pig organs, and US clinical trials for pig livers and kidneys were approved this year.
- Researchers observed swelling within 24 hours and antibody-mediated rejection on days 3 and 6 in the left lung from a donor pig, 70-kilogram male, yet it stayed viable for 216 hours.
- At the family's request the experiment was halted on day nine, researchers cautioned significant challenges remain and the recipient's right lung stayed in place, limiting conclusions on clinical readiness.
- Researchers say the study is a first step toward feasibility, as study authors describe lung xenotransplantation potential to reduce donor dependence; US clinical trial approvals this year support this trend.
Insights by Ground AI
Does this summary seem wrong?
53 Articles
53 Articles
Doctors transplanted the pig lung after obtaining consent from the man's family
According to hearts, kidneys and a liver, researchers have now also inserted a pig's lung into a human being.
·Zürich, Switzerland
Read Full Article
Coverage Details
Total News Sources53
Leaning Left11Leaning Right4Center17Last UpdatedBias Distribution53% Center
Bias Distribution
- 53% of the sources are Center
53% Center
L 34%
C 53%
13%
Factuality
To view factuality data please Upgrade to Premium
