PI3K/AKT Signaling Mediates Stress-Inducible Amyloid Formation Through C-Myc - Science in Vancouver

PI3K/AKT Signaling Mediates Stress-Inducible Amyloid Formation Through C-Myc - Science in Vancouver

In response to environmental stress, eukaryotic cells reversibly form functional amyloid aggregates called amyloid bodies (A-bodies). While these solid-like biomolecular condensates share many biophysical characteristics with pathological amyloids, A-bodies are non-toxic, and they induce a protective state of cellular dormancy. As a recently identified structure, the modulators of A-body biogenesis remain uncharacterized, with the seeding noncod…