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Pfizer’s Ultra-Long-Acting Injectable GLP-1 RA Shows Robust and Continued Weight Loss with Monthly Dosing in Phase 2b Trial

PF'3944 achieved up to 12.3% placebo-adjusted weight loss at week 28 with monthly dosing, showing sustained efficacy and favorable tolerability in a Phase 2b obesity study.

  • On Tuesday, Pfizer Inc. shared topline VESPER-3 Phase 2b results showing PF'3944 produced up to 12.3% mean placebo-adjusted weight loss at week 28 in adults with obesity or overweight without type 2 diabetes.
  • Soon after the Metsera acquisition closed, Pfizer added PF'3944 via a $10 billion deal and is pursuing monthly dosing to improve adherence in its obesity portfolio.
  • The 64-week study randomized VESPER-3 participants to weekly induction then monthly maintenance, testing four dosing regimens that all outperformed placebo at week 28 with mild or moderate side effects and nearly 10% discontinuations.
  • Pfizer plans to advance ten Phase 3 trials with PF'3944 in 2026 and will test a pivotal 9.6 mg high monthly dose later this year, while investors pushed shares down as analysts compared results with rivals.
  • PF'3944's long half-life positions it differently from weekly GLP-1s, with Pfizer targeting potential approvals starting in 2028 and pursuing combination strategies despite competition from Eli Lilly and Novo Nordisk.
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Pfizer says obesity injection shows promise as monthly treatment in mid-stage trial

The data on Pfizer's GLP-1 offer early evidence that the injection can be administered less frequently than existing drugs without sacrificing efficacy.

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Business Wire broke the news in Crystal River, United States on Monday, February 2, 2026.
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