Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis

Metabolic activity of CYP2C19 and CYP2D6 on antidepressant response from 13 clinical studies using genotype imputation: a meta-analysis

Cytochrome P450 enzymes including CYP2C19 and CYP2D6 are important for antidepressant metabolism and polymorphisms of these genes have been determined to predict metabolite levels. Nonetheless, more evidence is needed to understand the impact of genetic variations on antidepressant response. In this study, individual clinical and genetic data from 13 studies of European and East Asian ancestry populations were collected. The antidepressant respo…

One in five people will suffer from depression in their lifetime. These figures from the CNRS recall the importance of managing mental disorders, much less marginal than one might think. If therapeutic and drug treatments have democratized, they do not offer a solution for all patients. According to a study published in the Journal of Epidemiology and Public Health, between 15% and 30% of depressive patients would have a treatment-resistant depr…

Personalised Care Brings New Hope for Patients with Difficult-to-Treat Depression

A personalised, multidisciplinary approach has helped one patient overcome years of unresolved depression where medication alone failed. The post Personalised Care Brings New Hope for Patients with Difficult-to-Treat Depression appeared first on Psychreg.