Australia scientists closer to Hendra virus vaccine thanks to nanobodies from Chilean alpaca named Pedro
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A nanobody-based therapeutic targeting Nipah virus limits viral escape - Nature Structural & Molecular Biology
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic henipaviruses without approved human vaccines or therapies. Here, we report on a highly potent bispecific therapeutic that combines an anti-fusion glycoprotein nanobody with an anti-receptor-binding glycoprotein (RBP) antibody to deliver a dual-targeting biologic that is resistant to viral escape. We show that the nanobody, DS90, engages a unique, conserved site within the fusion gly…
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