Pathology-oriented multiplexing enables integrative disease mapping

New advanced imaging technology enables detailed disease mapping in tissue samples

Researchers from Aarhus University—in a major international collaboration—have developed a groundbreaking method that can provide more information from the tissue samples doctors take from patients every day.

Pathology-oriented multiplexing enables integrative disease mapping

The expression and location of proteins in tissues represent key determinants of health and disease. Although recent advances in multiplexed imaging have expanded the number of spatially accessible proteins1–3, the integration of biological layers (that is, cell structure, subcellular domains and signalling activity) remains challenging. This is due to limitations in the compositions of antibody panels and image resolution, which together restri…

Pathology Multiplexing Revolutionizes Disease Mapping

In a groundbreaking study that promises to redefine how we understand immune-mediated kidney disease, researchers have unveiled PathoPlex, a cutting-edge multiplexing technology that offers unprecedented insight into the cellular and molecular mechanisms driving renal pathology. By harnessing the power of spatially resolved, high-dimensional imaging, this innovative platform allows scientists to map disease processes at a nanometric resolution, …