US EditionOzempic, Wegovy could reverse severe liver disease, study suggests
- A global phase 3 study, recently featured in a leading medical journal, demonstrated that semaglutide effectively decreases liver fat and inflammation in individuals suffering from metabolic dysfunction-associated steatohepatitis .
- The study involved 800 mostly obese patients with moderate to advanced liver scarring and about half had type 2 diabetes, who received weekly semaglutide or placebo injections over 72 weeks to evaluate liver improvements.
- Among those receiving semaglutide, 62.9% experienced significant decreases in liver fat and inflammation without worsening scarring, compared to 34.3% in the placebo group. Additionally, fibrosis improvement was observed in 36.8% of the semaglutide group versus 22.4% of participants on placebo, alongside an average weight loss of 10.5%, compared to 2% in the placebo cohort.
- The study’s lead researcher from Virginia Commonwealth University emphasized that weight loss played a significant role in the trial’s outcomes, and semaglutide’s effects on metabolism might also contribute to slowing the progression of liver disease and associated health issues.
- If approved by the FDA, semaglutide could provide a vital new treatment option for millions with MASH, a disease with limited therapies, potentially addressing both liver damage and underlying metabolic dysfunction.
11 Articles
11 Articles
To sow a seed of doubt: Liver damage from natural products
By Hayden Stutz, Student Pharmacist and Karen L. Kier, Pharmacist On behalf of ONU Healthwise Pharmacy To sow a seed of doubt means to cause someone to have doubts, worries, or concerns. The sower of the seed conveys that someone is planting information into your head, creating doubt. A recent study may be planting a seed!Section: Health
Semaglutide found to have shocking benefit for liver disease patients in new study
Breakthrough research shows semaglutide effectively reverses life-threatening liver disease MASH, demonstrating significant inflammation reduction in 62.9% of clinical trial participants.
Landmark Study Finds Wegovy, Ozempic, Effectively Treat Serious Liver Disease
New research shows Wegovy (semaglutide) may treat both liver damage and underlying metabolic issues. Credit: Ark. Agricultural Experiment Station / CC BY-SA 2.0 Semaglutide, the active ingredient in Wegovy and Ozempic—a drug widely known for treating diabetes and aiding weight loss—may also help people suffering from a severe form of fatty liver disease, according to new research published in the New England Journal of Medicine. An international…
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