US EditionCAR T Therapy Induces Remission in Multiple Autoimmune Diseases
The experimental treatment ended daily blood transfusions and drove complete remission within 25 days, researchers said.
- A 47-year-old woman in Germany has entered complete remission after receiving experimental CAR-T cell therapy for three autoimmune diseases—AIHA, APLAS, and ITP—doctors at University Hospital Erlangen report.
- Her condition had become life-threatening, as rogue B cells attacked her tissues, requiring daily blood transfusions and multiple failed medications over a decade.
- Hematologist Fabian Müller isolated the patient's T cells, engineering them to target CD19 proteins on B cells before reinfusing them to eliminate the rogue cells.
- Symptoms improved within weeks; the patient no longer requires transfusions and has returned to an almost normal life, even working at the clinic where she was treated.
- Müller suggests that intervening earlier with CAR-T therapy could prevent long-term organ damage for other patients with severe autoimmune conditions, avoiding complications from years of ineffective treatments.
17 Articles
17 Articles
Suddenly, scientists were able to use innovative cell therapy called CAR-T Cell, to treat a patient with three different and potentially fatal autoimmune diseases, which had been resistant to treatment for years. The details of the case were published on this Thursday, as an article in the scientific magazine Med, of Cell Press. How to prevent black clothes from disappearing? Configure these practices to care for the pieces Bola pré front! The o…
For the first time, scientists at Erlangen University Hospital in Germany have used CAR-T cell therapy to treat a patient with three life-threatening autoimmune diseases who had resisted years of treatment. The patient, who previously required daily blood transfusions, has been in remission for one year without any additional treatment since CAR-T therapy began. The case report, published in Cell Press’s Med magazine, suggests that CAR-T therapi…
Woman With 3 Autoimmune Diseases Enters Remission After Immune 'Reset'
A patient with three different autoimmune diseases has entered complete remission after undergoing an experimental treatment that effectively reset her immune system. The 47-year-old woman in Germany previously required daily blood transfusions to manage her conditions, two of which affected her blood cells. She was given Chimeric Antigen Receptor (CAR-) T cell therapy, which involves extracting a sample of immune cells, 'supercharging' them aga…
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