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One shot or two? What to know about HPV vaccination recommendations

A Costa Rica study found one shot gave about 97% protection, as federal officials and doctors weigh a simpler HPV schedule.

  • Medical experts are discussing whether a single dose of the HPV vaccine might sufficiently protect preteens, potentially shifting away from the current two-dose standard. The American Academy of Pediatrics committee is actively exploring this guidance change.
  • A study tracking more than 20,000 girls found a single shot provided about 97% protection against cervical cancer, similar to two doses. However, experts note less evidence exists regarding protection against other HPV-related cancers in boys.
  • U.S. vaccination recommendations remain splintered after Health Secretary Robert F. Kennedy Jr. attempted a unilateral reduction to one dose earlier this year. A federal judge blocked that order, though medical groups continue evaluating independently.
  • Vaccinated males are nearly 50% less likely to develop several types of cancer, according to the University of Minnesota's Vaccine Integrity Project. "The duration of protection is long," said Angela Ulrich, who led the review.
  • Experts currently advise that children receive two shots to ensure full protection. Yale University vaccine policy researcher Jason Schwartz noted any change would be a significant shift from long-standing communication about adolescent health.
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The Toronto StarThe Toronto Star
+27 Reposted by 27 other sources
Lean Left

One shot or two? What to know about HPV vaccination recommendations

NEW YORK (AP) — Preteens may soon have something to celebrate: Medical experts are discussing the possibility that one dose of a life-saving cancer vaccine, instead of two, may be enough to protect them.

·Toronto, Canada
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Durango Herald broke the news on Saturday, September 26, 2026.
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