NRF1 Drives Mitochondrial Defense Against Ischemia Damage

NRF1 Drives Mitochondrial Defense Against Ischemia Damage

In a groundbreaking development that could redefine therapeutic strategies for ischemia reperfusion injury, recent research highlights the pivotal role of NRF1, a master regulator of mitochondrial function, in orchestrating cellular adaptations aimed at mitigating oxidative stress and inflammatory responses. This discovery sheds new light on the intricate molecular mechanisms that cells deploy to combat the damaging effects of ischemia reperfusi…

AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

AARS2, an alanyl-tRNA synthase, is essential for protein translation, but its function in mouse hearts is not fully addressed. Here, we found that cardiomyocyte-specific deletion of mouse AARS2 exhibited evident cardiomyopathy with impaired cardiac function, notable cardiac fibrosis, and cardiomyocyte apoptosis. Cardiomyocyte-specific AARS2 overexpression in mice improved cardiac function and reduced cardiac fibrosis after myocardial infarction …