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Omeros Skyrockets On $2.1B Novo Nordisk Rare Disease Deal - Novo Nordisk (NYSE:NVO), Omeros (NASDAQ:OMER)

Novo Nordisk will pay up to $2.1 billion to develop zaltenibart, targeting rare blood and kidney disorders with positive phase 2 data in paroxysmal nocturnal hemoglobinuria.

  • On Wednesday, Novo Nordisk agreed to acquire exclusive global rights to zaltenibart from Omeros Corporation in a deal valued at up to $2.1B including milestones.
  • Earlier this year, Omeros Corporation paused the zaltenibart programme despite positive phase 2 data in paroxysmal nocturnal hemoglobinuria, aligning with Novo Nordisk's rare-disease push under Mike Doustdar.
  • The agreement includes $340 million upfront, near-term milestones and tiered royalties to Omeros, which retains rights to preclinical MASP-3 programmes and small-molecule MASP-3 inhibitors.
  • Omeros' stock surged, nearly tripling from about $4 to just over $4 with a session volume of 89.21 million, as Novo Nordisk plans phase 3 trials in PNH.
  • Mechanistically, zaltenibart blocks MASP-3 to inhibit the alternative complement pathway, potentially preserving the classical complement pathway, and offers intravenous infusion every eight weeks.
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BizToc broke the news in on Wednesday, October 15, 2025.
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